EN
EN CN
R&D Pipeline
The pipelines are aiming to
Best-in-Class or First-in-Class
with great druggability and market potential
PRODUCT UNDER DEVELOPMENT
ESG401
Best-in-Class Trop2 ADC
Significant safety advantages
  • Indications

    Targeting multiple major indications, including metastatic HR+/HER2- breast cancer, triple-negative breast cancer;

    Non-small cell lung cancer, as well as various urological and gynecological tumors.

  • Development Progress

    Entered Phase III clinical trials in China.

PRODUCT UNDER DEVELOPMENT
ESG206
First-in-Class Monoclonal Antibody
Targeting in B-Cell Mediated Autoimmune Diseases and Relapsed/Refractory Malignancies
  • Indications

    B-cell malignancies, autoimmune diseases.

  • Development Progress

    Phase I dose-escalation trial in lymphoma completed, well-tolerated in lymphoma patients; efficacy demonstrated in relapse and resistant lymphoma patients.

    Phase I/II clinical study for relapsed/refractory primary immune thrombocytopenia (ITP) has shown significant efficacy and well tolerated with favorable safety profile.

    Planned initiation of a clinical study for Primary Sjögren's Syndrome (pSS).

Clinical Pipelines
Drugs
Product Name
Target
Indications
Preclinical
Preclinical
IND
Phase I
Phase II
Phase III
Remarks

mAb Drugs

  • ESG206
    BAFF-R
    B-cell Tumors Malignancy
    中国
    英国

  •  

    Autoimmune Diseases
    中

ADC Drugs

  • ESG401
    Trop-2
    Breast Cancer
    中国
    1

  • ESG403
    **
    Solid tumors

  • ESG406
    **
    GI solid tumor
    lung cancer

  • ESG407
    DLL3
    SCLC

  • ESG408
    **
    Solid tumors
    Co-developed with Foreseen Biotech, out-licensed to Ipsen

  • ESG409
    B7-H3
    NSCLC etc

  • ESG411
    Bispecific
    NSCLC etc

  • ESG412
    Bispecific
    Solid tumors

  • ESG413
    Bispecific
    Solid tumors

  • ESG414
    **

  • ESG416
    **

  • ESG421
    **
    Solid tumors